That’s where vitamins D3 and K2 enter the scene. In this day and age, it’s important to invest in your health using the most up-to-date science. New research is revealing this game-changing pair of vitamins and their effect on our hearts, our bones, and our blood sugar. Conclusions: The combination of vitamin K and D can significantly increase the total BMD and significantly decrease undercarboxylated osteocalcin, and a more favorable effect is expected when vitamin K 2 is used.Supplementing vitamin D3 and K2 comes with all the benefits of vitamin D and vitamin K, but also some unique health benefits that are only unlocked when these two vitamins are used together.

Simultaneously, subgroup analysis showed that K 2 or vitamin K (not specified) supplement was less than 500 μg d −1, which when combined with vitamin D can significantly increase the total BMD compared with the control group fed a normal diet or the group with no treatment (0.479, 0.101 to 0.858 and 0.570, 0.196 to 0.945). A significant decrease in undercarboxylated osteocalcin (−0.945, −1.113 to −0.778) can be observed with the combination of vitamin K and D. Vitamin K combined with vitamin D significantly increased the total bone mineral density (BMD): the pooled effect size was 0.316. Method and findings: A comprehensive search on Web of Science, PubMed, Embase and the Cochrane Library (from 1950 to February 2020) and bibliographies of relevant articles was undertaken, with the meta-analysis of eight randomized controlled trials (RCTs) including a total of 971 subjects. Background: Previous studies did not draw a consistent conclusion about the effects of vitamin K combined with vitamin D on human skeletal quality.

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